| 摘要 |
A process for the selective removal of a component from a liquid phase and subsequently returning the component to a liquid phase is disclosed. A novel compound of formula (I) [SUP]-[[L]-[G]]a (I) in which L is a linking group, G is an aryl group having a leaving group LG selected from Cl, Br, I, sulfonate such as triflate, a diazo group, a nitrile, an ester and an alkoxy group and substituent Q is selected from H, NR2, OR, C02R, F, Cl, N02 CN and SUP is a support having a plurality of groups -[L]-[G] bound to the support is contacted with the liquid phase to bind the component to the compound I thereby forming a captured component which is separated from and may be returned to the liquid phase. The compound I is especially useful in binding homogeneous catalysts to remove it from a reaction medium and selectively returning the catalyst to the reaction medium at a later stage. The compound is particularly useful for cross-coupling reactions, for example in Suzuki reactions. |
| 主权项 |
1. A process for the selective removal of a component from a liquid phase medium and subsequently returning the component to a liquid phase medium comprising contacting a compound of formula I below with the liquid phase medium to bind the component to the compound I thereby forming a bound component, separating the bound component and the medium, subsequently returning the bound component to the medium and treating the bound component so as to release the component from compound I wherein the compound I is of formula:
[SUP]-[[L]-[G]]a (I) wherein: L is a group linking G to SUP- and is selected from:
i) —(CH2)h[S(O)d]m(CHD)nZm((CH2)nY(CH2)n)m where D is selected from H, CN, OH, —C(O)OR, —C(O)NR2, —C(O)OG, —CONRG and Y is selected from O, NR, S(O)d, CO, CO2, —NRCOZm—, —ZmCONR—, —C═N—, a heterocyclic ring where Z is independently O, S, NR; andii) —(CH2)hP(═O)(OR)O—(CH2)h and wherein d is independently 0 to 2, h is from 0 to 15, m is independently 0 or 1 and n is independently 0 to 4 and R is independently selected from H or a C1-12 alkyl group and a phenyl group; or L is not present and G is linked directly to SUP; G is selected from an alkyl group, an aryl group, a heterocyclic group and a heteroaryl group wherein the group G has
a. a leaving group LG; andb. substituent Q selected from H, NR2, N+R3, —N(R)CO2H, —N═CR2, OR, —O+(R)SiR3, CO2R, CO2−, —CONR2, —NRC(O)R, F, Cl, NO2, CN and a ring formed between group Q and a part of group L, for example —O—C(O)— where the ether oxygen is bound to G and the carbonyl group is a part of group L; SUP is a support having a plurality n of groups -[L]-[G] bound to the support. |
