| 主权项 |
1. A compound of Formula I, or tautomer thereof, and/or a pharmaceutically acceptable salt thereof; wherein A1, A2, A3, A4, A5 and A6 are independently selected from the group consisting of CH, CR3 and N, provided that no more than four of A1, A2, A3, A4, A5 and A6 are N; R1 is selected from the group consisting of phenyl, 5-membered heteroaryl and 6-membered heteroaryl, wherein the phenyl, 5-membered heteroaryl or 6-membered heteroaryl is optionally substituted with 1 to 3 R6; L2 is selected from the group consisting of a covalent bond, —NR8—, —C(O)NR8—, —NR8C(O)—, —C(O)CR82—, —CR82C(O)—, —NR8CR82—, and —CR82NR8—; R2 is H, lower alkyl, 6- to 10-membered aryl or 5- to 10-membered heteroaryl; wherein the 6- to 10-membered aryl or 5- to 10-membered heteroaryl is optionally substituted with 1 to 4 R4, wherein each R4 is independently selected from the group consisting of lower alkyl, lower haloalkyl, phenyl (optionally substituted with lower alkyl, halo, lower haloalkyl, or —OH), —OH, —OR7, —SH, —SR7, —NR10R10, halo, cyano, nitro, —COH, —COR7, —CO2H, —CO2R7, —CONR10R10, —OCOR7, —OCO2R7, —OCONR10R10, —NR10COR7, —NR10CO2R7, —SOR7, —SO2R7, —SO2NR10R10, and —NR10SO2R7; each R3 is independently selected from the group consisting of lower alkyl, lower haloalkyl, —OH, —OR7, —SH, —SR7, —NR10R10, halo, cyano, nitro, —COH, —COR7, —CO2H, —CO2R7, —CONR10R10, —OCOR7, —OCO2R7, —OCONR10R10, —NR10COR7, —NR10CO2R7, —SOR7, —SO2R7, —SO2NR10R10, and —NR10SO2R7; q is 1, 2 or 3; each R6 is independently selected from the group consisting of cyano, halo, lower alkyl, lower haloalkyl, and —CH2OH; R7 is lower alkyl or lower haloalkyl; R8 is hydrogen or lower alkyl; each R10 is independently hydrogen or lower alkyl, or two R10 together with the atom(s) attached thereto form a 4- to 6-membered ring; and R11 is hydrogen or R3; provided that the compound is not N-(1-(4-(trifluoromethyl)benzyl)-1H-indazol-3-yl)furan-2-carboxamide. |
