Methods and Compositions for treatment of cancer by inhibition of NR2F2

摘要

The current invention discloses compositions of matter, protocols and methods of use of treatment for cancer and other diseases of aberrant cellular proliferation and differentiation by inhibiting expression of NR2F2 or activity thereof. In one embodiment, administration of synthetic oligonucleotides that induce RNA interference mediated degradation of the nuclear receptor NR2F2 in human or animal patients is performed at a sufficient concentration or frequency to achieve regression of tumor.

主权项

1. A method of treating cancer in a subject comprising, identifying a subject suffering from a cancer condition, administration to said subject having said cancerous condition an effective amount of a composition comprising a synthetic oligonucleotide complementary to a nuclear receptor having a mRNA sequence of at least 75% sequence identity to the mRNA sequence of SEQ ID NO: 1, 2, 3 or 4 that induces the RNA interference, wherein said nucleotide comprises a sense oligonucleotide strand and an antisense oligonucleotide strand, wherein the sense and antisense oligonucleotide strands form a duplex, and wherein the sense oligonucleotide strand comprises a portion of SEQ ID NO:1, 2, 3 or 4 that has been selected based on its ability to inhibits the expression of the nuclear receptor NR2F2 by causing degradation of a ribonucleic acid encoding nuclear receptor NR2F2 by activation of RNA interference.