| 发明名称 |
METHODS FOR TREATING RENAL DISEASE |
| 摘要 |
The invention features methods for treating or reducing the likelihood of developing a renal disease by administering to a subject in need thereof an agent that decreases expression of a pathogenic APOL1. The agents of the method target various signaling pathways and decrease the level of the pathogenic APOL1 polypeptide. |
| 申请公布号 |
US2015297598(A1) |
申请公布日期 |
2015.10.22 |
| 申请号 |
US201314646055 |
申请日期 |
2013.11.20 |
| 申请人 |
BETH ISRAEL DEACONESS MEDICAL CENTER, INC. |
发明人 |
FRIEDMAN David J.;POLLAK Martin R. |
| 分类号 |
A61K31/519;A61K45/06;A61K31/4706;A61K31/517;A61K31/429;A61K31/506 |
主分类号 |
A61K31/519 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of treating or reducing the likelihood of developing a renal disease comprising administering to a subject in need thereof an agent that decreases the level of expression of a pathogenic APOL1 polypeptide encoded by an APOL1 risk allele relative to the level of APOL1 polypeptide expression in the absence of said agent. |
| 地址 |
Boston MA US |
