ANALGESIC

摘要

An object of the present invention is to provide an analgesic effective in a prophylactic or a therapy for various pain diseases. The present invention is to provide an analgesic containing at least one member selected from a trans-2-decenoic acid derivative represented by the formula (1) and a pharmaceutically acceptable salt thereof as an active ingredient:;;(In the formula, Y is —O—, —NR— or —S—, R is hydrogen atom, alkyl group, dialkylaminoalkyl group or the like and W is a substituent such as dialkylaminoalkyl group). The analgesic of the present invention containing the compound as an active ingredient is highly useful as a prophylactic or therapeutic agent for various pain diseases such as the pain caused by osteoarthritis (e.g., knee osteoarthritis and hip osteoarthritis).

主权项

1. A method of treating pain comprising administering an effective amount of at least one member selected from a trans-2-decenoic acid derivative and a pharmaceutically acceptable salt thereof as an active ingredient to a subject in need thereof, wherein the trans-2-decenoic acid derivative is represented by the following formula (1): wherein Y is —O—, —NR— or —S—; W is W1 when Y is —O—, W2 when Y is —NR— or W3 when Y is —S—; (1) W1 is dialkylaminoalkyl group, alkylthioalkyl group, alkoxyalkyl group, dialkoxyalkyl group or dialkylaminoalkoxyalkyl group; (2-1) W2 is hydrogen atom, alkyl group or dialkylaminoalkyl group when R is dialkylaminoalkyl group; (2-2) W2 is alkyl group which is same as or different from R when R is alkyl group; or (2-3) W2 is alkyl group, cycloalkyl group, pyrrolidinealkyl group, phenyl group or phenylalkyl group when R is hydrogen atom; and (3) W3 is alkyl group, cycloalkyl group, phenylalkyl group or dialkylaminoalkyl group.