SiOx BARRIER FOR PHARMACEUTICAL PACKAGE AND COATING PROCESS

摘要

A vessel including a thermoplastic wall enclosing a lumen is disclosed. The wall supports an SiOx composite barrier coating or layer, for which x is from 1.8 to 2.4, between the wall and the lumen. High Resolution X-ray Photoelectron Spectroscopy (XPS) shows the presence of an interface between the composite barrier coating or layer and the wall or substrate. In one aspect, the interface has at least 1 mol.% O3—Si—C covalent bonding, as a proportion of the O3—Si—C covalent bonding plus SiO4 bonding. In another aspect, the interface has an Si 2p chemical shift to lower binding energy (eV), compared to the binding energy of SiO4 bonding. The result is a tightly adherent composite barrier coating or layer having a high degree of adhesion to the substrate under practical use conditions. Methods of applying the composite barrier coating or layer are also disclosed.

主权项

1. A vessel comprising a thermoplastic wall enclosing a lumen and an SiOx composite barrier coating or layer, for which x is from 1.8 to 2.4, supported by the wall between the wall and the lumen,
an interior surface of the composite barrier coating or layer facing the lumen, and a pH protective coating or layer of SiOxCy or SiNxCy wherein x is from about 0.5 to about 2.4 and y is from about 0.6 and about 3, the pH protective coating or layer having an interior surface facing the lumen and an outer surface facing the interior surface of the composite barrier coating or layer, the pH protective coating or layer being effective to increase the calculated shelf life of the vessel (total Si/Si dissolution rate), in which the degree of retention of the composite barrier coating or layer on the substrate is at least 95%, by the Coated Article Cross-Scratch Tape Test Method.