发明名称 METHODS AND COMPOSITIONS FOR TARGETING CANCER STEM CELLS
摘要 The present invention relates to chemical compounds, methods for their discovery, and their therapeutic and research use. In particular, the present invention provides compounds as therapeutic agents against cancer stem cells.
申请公布号 US2015297577(A1) 申请公布日期 2015.10.22
申请号 US201314647770 申请日期 2013.11.26
申请人 The Regents of the University of Michigan 发明人 Buckanovich Ronald;Larsen Scott D.;Yang Kun
分类号 A61K31/4439;A61K45/06;A61K31/437;A61K31/136;A61K31/4035 主分类号 A61K31/4439
代理机构 代理人
主权项 1. A composition comprising a compound that inhibits aldehyde dehydrogenase (ALDH), wherein said compound has the structurewherein R1 and R2 are independently or together selected from the group consisting of H, an alkyl, a cycloalkyl, together form a cycloalkyl or heterocyclic alkyl or aryl, an aryl, an alkenyl, a cycloalkyl, alkynl, and a substituted version of the aforementioned groups; and R3-R6 are independently selected from the group consisting of a halogen, H, an alkyl, a cycloalkyl, an aryl, an alkenyl, a cycloalkyl, alkynl, and a substituted version of the aforementioned groups.
地址 Ann Arbor MI US