| 主权项 |
1. A method of treating systemic disease in oral biofilms having a facultative anaerobic bacteria pathogen present within a subgingival biofilm associated with the oral biofilm wherein the subgingival biofilm has a protein layer and an amino acid comprising:
providing a periodontal medicament delivery tray having a seal against the patient's adjacent gums containing the oral biofilms having the systemic disease, said seal formed so as to have no contact with teeth; applying an antimicrobial agent to a subgingival portion of a tooth and a gingival tissue surrounding the tooth by filling at least a portion of the periodontal medicament delivery tray with the antimicrobial agent and attaching the delivery tray about the gingival tissue; the applying of the antimicrobial agent penetrating the subgingival biofilm and the gingival tissue associated with such subgingival biofilm wherein the determining and applying are repeated a plurality of times until an environment associated with the subgingival biofilm is altered from anaerobic to aerobic, killing the determined facultative bacteria pathogen, modifying the protein layer, and altering the amino acid associated with the subgingival biofilm to cleave hyaluronic acid, convert histadine to alanine and asparagine to aspartate; surgically removing the determined facultative anaerobic bacteria from the gingival tissue that is remaining and that is imbedded following the applying of the antimicrobial agent that obtains the aerobic environment associated with the subgingival biofilm, the killing of the determined facultative bacteria pathogen, the modification of the protein layer and the altering of the amino acid; administering a colloidal hydrogen peroxide gel to a periodontal pocket or a sulcus associated on the gingival tissue, the subgingival biofilm and the gingival tissue in conjunction with or following the surgically removing of at least a portion of the imbedded anaerobic bacteria to chemically remove a further portion of the imbedded anaerobic bacteria not removed during the prior surgical removing process, wherein administering includes filling at least a portion of the periodontal medicament delivery tray with the colloidal hydrogen peroxide gel and attaching the delivery tray about the gingival tissue associated with the periodontal pocket; repeating the administering of the colloidal hydrogen peroxide gel on a periodic basis for maintaining an environment conducive to only aerobic bacteria; and cleaning the gingival tissue with a cleaning agent directly following each administering of the colloidal hydrogen peroxide gel. |
