| 摘要 |
<p>The present invention relates to a preparation method for hyaluronic acid having a low degradation rate in the body, and an anti-adhesive composition comprising hyaluronic acid prepared by the preparation method. More specifically, the present invention provides a preparation method for hyaluronic acid having a low degradation rate in the body, comprising a step for culturing Streptococcus dysgalactiae strain 9103 (KCTC11818BP) in a medium comprising a carbon source and a nitrogen source, and an anti-adhesive composition comprising hyaluronic acid prepared by the preparation method. The hyaluronic acid prepared by the preparation method of the present invention is a high-molecular hyaluronic acid of 3.5 million Da to 10 million Da, and has an excellent anti-adhesive effect due to slow degradation rate in the body. The anti-adhesive composition of the present invention, comprising hyaluronic acid prepared by the preparation method of the present invention, is capable of improving the problems of conventional anti-adhesive compositions comprising crosslinking agents and compounds, and the problems of conventional hyaluronic acid, by using non-crosslinked hyaluronic acid.</p> |
