发明名称 |
METHOD FOR REPROGRAMMING OF HUMAN DENTAL PULP CELL USING OCT4 AND SOX2 AND USE THEREOF |
摘要 |
The present invention relates to a method for producing endothelial progenitor cells, comprising a method for producing induced pluripotent stem cells by using only Oct4 and Sox2 as a reprogramming factor of human dental pulp cells, and differentiating endothelial progenitor cells from the induced pluripotent stem cells produced by the method for producing induced pluripotent stem cells. Moreover, the present invention relates to a method for producing endothelial cells, comprising differentiating endothelial cells from endothelial progenitor cells produced by the method for producing the endothelial progenitor cells. Additionally, the present invention relates to a method for producing smooth muscle cells, comprising differentiating smooth muscle cells from endothelial progenitor cells produced by the method for producing the endothelial progenitor cells.;Also, the present invention make a significant contribution to treatment of ischemia disease and heart disease because a patient's dental pulp cell-derived differentiated cells can be used for cell treatment as a result of the cell treatment effect of the endothelial progenitor cells in a mouse model induced to have hind limb ischemia or myocardial infarction. |
申请公布号 |
US2015299665(A1) |
申请公布日期 |
2015.10.22 |
申请号 |
US201414340991 |
申请日期 |
2014.07.25 |
申请人 |
KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY |
发明人 |
Cho Yee Sook;Yoo Chae Wha;Na Hee Jun |
分类号 |
C12N5/074;A61K35/12;C12N5/071 |
主分类号 |
C12N5/074 |
代理机构 |
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代理人 |
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主权项 |
1. A method for producing induced pluripotent stem cells from human dental pulp cells, comprising using only Oct4 and Sox2 as a reprogramming factor. |
地址 |
Daejeon KR |