A method for crystallizing insulin or insulin analogs under alkaline conditions and purifying the insulin or insulin analog crystals by filtering through a filter and drying the insulin or insulin analog crystals captured on the filter to produce crystalline insulin or insulin analog crystal compositions is described. In particular aspects, the method may be used to crystalize insulin glargine.
申请公布号
WO2015084694(A3)
申请公布日期
2015.10.22
申请号
WO2014US67847
申请日期
2014.12.01
申请人
MERCK SHARP & DOHME CORP.;ORTIGOSA, ALLISON D.;PERRY, WILLIAM;SLEEVI, MARK C.;SIERRA, LUIS
发明人
ORTIGOSA, ALLISON D.;PERRY, WILLIAM;SLEEVI, MARK C.;SIERRA, LUIS