| 发明名称 |
Agents That Modulate Immune Cell Activation and Methods of Use Thereof |
| 摘要 |
The present invention relates to compositions and methods for the immunomodulation mediated by the interaction of PD-L2 and RGMb. |
| 申请公布号 |
US2015299322(A1) |
申请公布日期 |
2015.10.22 |
| 申请号 |
US201314418548 |
申请日期 |
2013.08.02 |
| 申请人 |
DANA-FARBER CANCER INSTITUTE, INC. ;BOSTON CHILDREN'S HOSPITAL |
发明人 |
Freeman Gordon J.;Sharpe Arlene H.;Xiao Yanping;Francisco Loise;Dekruyff Rosemarie;Umetsu Dale |
| 分类号 |
C07K16/28;G01N33/68;A61K39/395;A61K45/06;C07K14/705 |
主分类号 |
C07K16/28 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for modulating an immune response comprising contacting a cell expressing PD-L2 or a cell expressing RGMb with an agent that modulates the interaction of PD-L2 with RGMb to thereby modulate the immune response. |
| 地址 |
Boston MA US |
