Alpha-CONOTOXIN PEPTIDE, PHARMACEUTICAL COMPOSITION AND USE THEREOF

摘要

The present invention provides a novel α-conotoxin peptide, pharmaceutical composition and use thereof. The present invention further provides a propeptide of the conotoxin peptide, a nucleic acid construct, expression vector and transformed cell of the conotoxin peptide as well as a fused protein of the conotoxin peptide. The present invention discloses a method for blocking acetylcholine receptors as well as a use of the conotoxin peptide in the manufacture of a medicament. The α-conotoxin peptide of the present invention can specifically block acetylcholine receptor (nAChRs, such as α3β2 nAChRs, α6/α3β2β3 nAChR or α3β4 nAChR or α6/α3β4 nAChR), has activity for treatment of neuralgia, addiction, Parkinson's disease, dementia, schizophrenia, cancers, and can be used in the manufacture of a medicament for analgesia and smoking cessation and drug-withdrawal, a medicament for treatment of mental diseases and cancers, as well as a tool drug for neurosciences.

主权项

1. A polypeptide, which has an amino acid sequence as shown in the following Formula I:
GCCSX1PX2CX3X4X5X6PX7X8CX9  Formula I wherein, X1 represents D or H, X2 represents P, A or V, X3 represents R, N or S, X4 represents N, V or A, X5 represents K, D, M or A, X6 represents H or S, X7 represents D, E or X7 is absent, X8 represents L or I, X9 represents G or X9 is absent.