| 发明名称 |
PR13.5 PROMOTER FOR ROBUST T-CELL AND ANTIBODY RESPONSES |
| 摘要 |
The invention encompasses recombinant poxviruses, preferably modified Vaccinia Ankara (MVA) viruses, comprising a Pr13.5 promoter operably linked to a nucleotide sequence encoding an antigen and uses thereof. The invention is drawn to compositions and methods for the induction of strong CD8 T cell and antibody responses to a specific antigen(s) by administering one or more immunizations of the recombinant MVA to a mammal, preferably a human. |
| 申请公布号 |
US2015299267(A1) |
申请公布日期 |
2015.10.22 |
| 申请号 |
US201314437939 |
申请日期 |
2013.10.28 |
| 申请人 |
BAVARIAN NORDIC A/S |
发明人 |
Steigerwald Robin;Brinkmann Kay |
| 分类号 |
C07K14/005;C12N15/86;C12N7/00 |
主分类号 |
C07K14/005 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of inducing a robust CD8 T cell response against a neoantigen in a human comprising administering one or more administrations of a recombinant modified Vaccinia Ankara (MVA) virus to the human;
wherein the recombinant MVA comprises a Pr13.5 promoter operably linked to a nucleotide sequence encoding the neoantigen, wherein the Pr13.5 promoter comprises at least 1 copy of a nucleic acid sequence of at least 40 bases having at least 95% identity with SEQ ID NO:1. |
| 地址 |
Kvistgaard DK |
