QUINOLYL HYDRAZONES FOR THE TREATMENT OF TUBERCULOSIS AND RELATED DISEASES

摘要

The invention provides quinolyl-hydrazones of Formula I, or pharmaceutically acceptable salts, esters, solvates, isomers and prodrugs thereof as well as pharmaceutical compositions containing these compounds for use in the prophylactic and/or therapeutic treatment of tuberculosis and related diseases, such as, diseases caused by nontuberculous mycobacteria and/or caused by Micobacterium leprae.

主权项

1. A compound of general Formula (I)for use in the treatment and/or prevention of tuberculosis and related diseases, as antimicrobial drug wherein
Q isand A is a 5-6 member substituted or unsubstituted aryl or heteroaryl ring selected from: wherein R1, R2 and R3 are each independently of one another, hydrogen, (C1-C4)alkyl, hydroxyl, halogen, methoxy or methoxy-acetic acid; and R4, R5, R6 and R7 are each independently of one another, hydrogen or (C1-C4)alkyl, or a pharmaceutically acceptable salt, ester, solvate, isomer or prodrug thereof.