COMPOSITIONS AND METHODS COMPRISING RHENIUM FOR THE TREATMENT OF CANCERS

摘要

Compositions and methods comprising rhenium are provided. In some embodiments, the rhenium compounds comprise a bidentate ligand. In some embodiments, the rhenium compounds are used in method for treating cancer.

主权项

1. A compound comprising Formula (I):wherein:is a bidentate ligand and X4 and X5 are the same or different and are selected from the group consisting of N, O, S, and P;
X1, X2, and X3 are the same or different and are selected from the group consisting of optionally substituted alkyl, optionally substituted heteroalkyl, halo, —CN, —OR′, —SR′, —SCN, —OCOR′, —OSO2, and —OPO3R′2; and each R′ is independently hydrogen, optionally substituted alkyl, optionally substituted heteroalkyl, optionally substituted aryl, or optional substituted heteroaryl.