MACROCYCLIC PURINES FOR THE TREATMENT OF VIRAL INFECTIONS

摘要

This invention relates macrocyclic purine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.

主权项

1. A compound having formula (I) or a pharmaceutically accepted salt thereof, wherein X is oxygen, nitrogen, sulfur or Y is an aromatic ring or heterocyclic ring comprising at least a nitrogen, optionally substituted by one or more substituents independently selected from C1-6alkyl, C1-4alkoxy, trifluoromethyl or halogen, and Z is C1-10 saturated or unsaturated alkyl optionally substituted by an alkyl or alkylhydroxyl; or Z is C1-6alkyl-NH—C(O)—C1-6alkyl- or C1-6alkyl-NH—C(O)—C1-6alkyl-O—; or Z is C1-10alkyl-O— wherein said alkyl is unsaturated or saturated and can optionally be substituted by an alkyl or alkylhydroxyl; or Z is C1-6alkyl-O—C1-6alkyl- wherein said alkyl is unsaturated or saturated and can optionally be substituted by an alkyl or alkylhydroxyl; or Z is C1-6alkyl-O—C1-6alkyl-O— wherein said alkyl is unsaturated or saturated and can optionally be substituted by an alkyl or alkylhydroxyl.