发明名称 PROCESS FOR THE PREPARATION OF N-HYDROXY-1-(1-ALKYL-1H-TETRAZOL-5-YL)-1-PHENYLMETHANIMINE DERIVATIVES
摘要 The present invention relates to a process for the preparation of N-hydroxy-1-(1-alkyl-1H-tetrazol-5-yl)-1-phenylmethanimine derivatives of the general formula (I);
申请公布号 US2015299145(A1) 申请公布日期 2015.10.22
申请号 US201314376931 申请日期 2013.02.06
申请人 BAYER INTELLECTUAL PROPERTY GMBH 发明人 COQUERON Pierre-Yves;DUBOST Christophe;FORD Mark;REBSTOCK Anne-Sophie
分类号 C07D257/04 主分类号 C07D257/04
代理机构 代理人
主权项 1. Process for the preparation of N-hydroxy-1-(1-alkyl-1H-tetrazol-5-yl)-1-phenylmethanimine derivatives of the general formula (I) in which R1 is phenyl optionally monosubstituted by halogen, cyano, nitro, C1-C8-alkyl, C1-C8-alkoxy, methylsulphonyl, trifluoromethyl or aryl, R2 is C1-C12-alkyl or C1-C12-haloalkyl, characterized in that (1) in a first step, 5-benzyl-1-methyl-1H-tetrazoles of the general formula (II) in which R1 and R2 have the meanings given above, are reacted with a nitrite derivative of the general formula (III) in which R3 is a C1-C12-alkyl in the presence of base with a pKa below 20.
地址 Monheim DE