| 主权项 |
1. A compound of Formula (I), or a pharmaceutically acceptable salt or hydrate thereof:wherein
each R1 is independently hydrogen or C1-6 alkyl; L1 is a bond or C1-6 alkylene; A1 is C3-8 cycloalkyl, aryl, heteroaryl or heterocyclyl; A2 is C3-8 cycloalkyl, aryl, heteroaryl or heterocyclyl; L2 is a bond or —NR5—; each R2 is independently halo, hydroxyl, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkoxy, C1-6 thioalkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, C1-6 alkyl-OH, aryl, aralkyl, aryloxy, —NO2, —C(O)—O—C1-6 alkyl, —S(O)2—NH-aryl, —S(O)2—C1-6 alkyl or —S(O)—C1-6 alkyl, wherein each said aryl moiety may be substituted with 0-3 occurrences of R6; R3 is C1-6 alkyl, C2-6 alkenyl, C3-8 cycloalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl or heterocyclyl, each of which may be substituted with 0-3 occurrences of R6; each R4 is independently halo, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkoxy, C1-6 thioalkyl, C3-8 cycloalkyl, C3-8 cycloalkenyl, aryl, heteroaryl, heterocyclyl, —S(O)—C1-6 alkyl, —S(O)2—C1-6 alkyl, —O-aryl, —O-heteroaryl, —O-heterocyclyl, —N(R5)—C1-6 alkyl or —N(R5)-aryl; each R5 is independently hydrogen or C1-6 alkyl; each R6 is independently halo, hydroxyl, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C3-8 cycloalkyl, cyano, NO2, —CO2H, —C(O)—C1-6 alkyl, —S(O)2—C1-6 alkyl, —O—S(O)2—C1-6 alkyl, —O—C1-6 alkyl-C(O)OH, —O—C1-6 alkyl-C(O)—O—C1-6 alkyl, —N(R5)—C(O)—C1-6 alkyl, —N(R5)—C1-6 alkyl-C(O)—O—C1-6 alkyl, aryl, heteroaryl or heterocyclyl; or adjacent R6 moieties, taken together with the atoms to which they are attached form a heterocyclyl; each R7 is independently C1-6 alkyl, C1-6 alkoxy, C3-8 cycloalkyl, hydroxyl, halo, —NHC(O)—C1-6 alkyl, —S(O)2—C1-6 alkyl, aryl, heteroaryl or heterocyclyl; and n is 0, 1, 2, 3 or 4; wherein when L1 is a bond, A1 and the adjacent N(R1) can be taken together to form a heterocyclic ring; and wherein when L2 is a bond, R3 is heterocyclyl; and provided that: (1) when L1 is a bond, L2 is a bond, A2 is phenyl, and R4 is methoxy, Cl, F, or methyl and R4 is para to the N(R1)C(O)N(R1) moiety, then R3 is not 1-piperidinyl, 1-pyrrolidinyl, N-morpholinyl, or N-azepanyl; (2) when L2 is —N(R5)— wherein R5 is H, A2 is phenyl, and R4 is methyl and R4 is para to the N(R1)C(O)N(R1) moiety, then R3 is not methyl; (3) when L2 is —N(R5)—, R5 is H, A2 is phenyl, and R4 is methyl and R4 is ortho to the N(R1)C(O)N(R1) moiety, then R3 is not methyl; (4) when L2 is —N(R5)—, R5 is H, A2 is phenyl, and R4 is methoxy and R4 is ortho to the N(R1)C(O)N(R1) moiety, then R3 is not cyclopropyl; (5) when L1 is a bond, A1 is phenyl, L2 is —N(R5)— wherein R5 is H, A2 is phenyl, and R4 is methyl, methoxy, Cl, 1-piperidiniyl, 1-pyrrolidinyl, N-morpholinyl, or N-azepanyl and R4 is ortho to the N(R1)C(O)N(R1) moiety, then R3 is not dodecyl or phenyl optionally substituted with 0-3 occurrences of R6; (6) when L2 is a bond, A2 is phenyl, and R4 is methyl, methoxy, ethoxy, Cl, OH, tetrahydro-2-furanylmethylamino, 4-methyl-piperazinyl, 4-ethyl-piperazinyl, 1-pyrrolidinyl, 1-piperidinyl, 4-methyl-1-piperidinyl, or —OCH2CF3 and R4 is ortho to the N(R1)C(O)N(R1) moiety, then R3 is not 1-piperidinyl, 1-pyrrolidinyl, N-morpholinyl or 4-methyl-1-piperidinyl; and (7) is not a compound selected from: N′-[4-ethoxy-3-(1-pyrrolidinylsulfonyl)phenyl]-N-methyl-N-(4-methylcyclohexyl)-urea; N-[5-chloro-3-[[[[4-chloro-3-[(dodecylamino)sulfonyl]phenyl]amino]carbonyl]amino]-2-hydroxyphenyl]-acetamide; 4-butyl-1-[3-[[[[4-chloro-3-[[[4-(2-formylhydrazinyl)phenyl]amino]sulfonyl]phenyl]-amino]-carbonyl]amino]propyl]-3,5-dimethyl-pyridinium; N-(2-methoxyphenyl)-5-[[[[1-methyl-1-[3-(1-methylethenyl)phenyl]ethyl]amino]-carbonyl]-amino]-2-(1-piperidinyl)-benzenesulfonamide; 2-chloro-N-(4-ethoxyphenyl)-5-[[[[1-methyl-1-[3-(1-methylethenyl)phenyl]ethyl]amino]carbonyl]amino]-benzenesulfonamide; 2-(diethylamino)-N-(2-methoxyphenyl)-5-[[[[1-methyl-1-[3-(1-methylethenyl)phenyl]ethyl]amino]carbonyl]amino]-benzenesulfonamide; N-(3-chlorophenyl)-2-methyl-5-[[[[1-methyl-1-[3-(1-methylethenyl)phenyl]ethyl]amino]carbonyl]amino]-benzenesulfonamide; 4-butyl-1-[3-[[[[4-chloro-3-[[[4-(2-formylhydrazinyl)phenyl]amino]sulfonyl]phenyl]amino]carbonyl]amino]propyl]-3,5-dimethyl-pyridinium chloride; N′-[4-chloro-3-(1-pyrrolidinylsulfonyl)phenyl]-N-methyl-N-[(2-methyl-5-thiazolyl)methyl]-urea; N′-[4-methoxy-3-(1-piperidinylsulfonyl)phenyl]-N-methyl-N-[(2-methyl-5-thiazolyl)methyl]-urea; N-[3-[(hexahydro-1H-azepin-1-yl)sulfonyl]-4-methylphenyl]-N′-[1-methyl-1-[3-(1-methylethenyl)phenyl]ethyl]-urea; N-butyl-4-methoxy-3-[[[[4-[6-(4-morpholinylmethyl)-3-pyridinyl]-1-naphthalenyl]amino]carbonyl]amino]-benzenesulfonamide; N-[3-[2,4-bis(1,1-dimethylpropyl)phenoxy]propyl]-4-chloro-3-[[[(3,5-dichloro-2-hydroxy-4-methylphenyl)amino]carbonyl]amino]-benzenesulfonamide; N-(2,5-dichlorophenyl)-4-(diethylamino)-3-[[[(4-nitrophenyl)amino]carbonyl]amino]-benzenesulfonamide; 3-[[[[6-[[4-[bis(2-cyanoethyl)amino]-2-methylphenyl]imino]-3,4-dicyano-5-(trifluoromethyl)-6H-pyrrolo[1,2-b]pyrazol-2-yl]amino]carbonyl]amino]-4-chloro-N-hexadecyl-benzenesulfonamide; 3-[[[[4-[[4-[bis(2-hydroxyethyl)amino]-2-methylphenyl]methylene]-2-phenyl-4H-imidazol-5-yl]amino]carbonyl]amino]-N-hexadecyl-4-methoxy-benzenesulfonamide; 3,3′-[(3,7-dichloro-5-oxo-1H,5H-diimidazo[1,2-a:2′,1′-d][1,3,5]triazine-2,8-diyl)bis(iminocarbonylimino)]bis[N-[3-(dodecyloxy)propyl]-4-methoxy-benzenesulfonamide; N-[2-(diethylamino)-5-(4-morpholinylsulfonyl)phenyl]-N′-(3-methylphenyl)-urea; N-[2-methyl-5-(1-piperidinylsulfonyl)phenyl]-N′-(3,5,7-trimethyltricyclo[3.3.1.13,7]dec-1-yl)-urea; N-(4-chlorophenyl)-N′-[5-(4-morpholinylsulfonyl)-2-(2-oxo-1-pyrrolidinyl)phenyl]-urea; and N-[2-chloro-5-[(hexahydro-1H-azepin-1-yl)sulfonyl]phenyl]-N′-(4-nitrophenyl)-urea. |
