MORPHOGENETICALLY ACTIVE HYDROGEL FOR BIOPRINTING OF BIOARTIFICIAL TISSUE

摘要

The invention relates to a combined system for three-dimensional (3D) bioprinting, based on encapsulating of cells into an alginate hydrogel or alginate/gelatin hydrogel, followed by an overlay comprising a morphogenetically active polymer, polyphosphate-calcium complex or biosilica, providing a useful matrix for the cells, including bone-forming cells, to proliferate and be become functionally active, for example, bone cells to mineralize.