| 发明名称 |
THERAPEUTIC APPLICATIONS OF P53 ISOFORMS IN REGENERATIVE MEDICINE, AGING AND CANCER |
| 摘要 |
The present invention provides methods and compositions for modulating cell senescence and cell proliferation using isoforms of the p53 tumor suppressor protein. The methods and compositions of the invention find use in inhibiting cancer cell growth or in generating populations of cells for tissue regeneration through the modulation of cell senescence and proliferation. |
| 申请公布号 |
US2015299706(A1) |
申请公布日期 |
2015.10.22 |
| 申请号 |
US201514754000 |
申请日期 |
2015.06.29 |
| 申请人 |
Department of Health and Human Services The United States of America as Represented by the Secretary of the;The University of Dundee ;Masaryk Memorial Cancer Institute |
发明人 |
Harris Curtis C.;Fujita Kaori;Horikawa Izumi;Vojtesek Borivoj;Bourdon Jean-Christophe;Lane David P. |
| 分类号 |
C12N15/113 |
主分类号 |
C12N15/113 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. A method of extending the replicative lifespan of a cell by inhibiting cell senescence, the method comprising the step of contacting the cell with an agent that inhibits the function or expression of p53β, thereby inhibiting cell senescence and extending the replicative lifespan of the cell. |
| 地址 |
Rockville MD US |
