| 发明名称 |
ENGINEERED LOWER EUKARYOTIC HOST STRAINS DEFICIENT IN GRR1 ACTIVITY FOR RECOMBINANT PROTEIN |
| 摘要 |
The present invention relates to novel engineered lower eukaryotic host cells for expressing heterologous proteins and to methods of generating such strains. Lower eukaryotic host cells can be engineered to produce heterologous proteins. Further, lower eukaryotic host cells can be glyco-engineered to produce glycoproteins where the N- or O-linked glycosylation are modified from their native forms. |
| 申请公布号 |
US2015299690(A1) |
申请公布日期 |
2015.10.22 |
| 申请号 |
US201314439746 |
申请日期 |
2013.12.05 |
| 申请人 |
JIANG Bo;ZHUANG Jun;MERCK SHARP & DOHME CORP. |
发明人 |
Jiang Bo;Zhuang Jun |
| 分类号 |
C12N9/00;C12P21/00 |
主分类号 |
C12N9/00 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. An engineered lower eukaryotic host cell that has a modified GRR1 gene. |
| 地址 |
US |
