| 发明名称 |
NOVEL MUCOSAL ADJUVANTS AND DELIVERY SYSTEMS |
| 摘要 |
Adjuvants comprising chitosan cross-linked with an aldehyde or mannosylated chitosan are provided herein. Methods of making the adjuvants and methods of combining or linking the adjuvants with antigens are also provided. The adjuvant-antigen combinations can be used in vaccine formulations and the vaccine formulations can be used in methods to vaccinate animals against the source of the antigen or to enhance the immune response in a subject. |
| 申请公布号 |
US2015297714(A1) |
申请公布日期 |
2015.10.22 |
| 申请号 |
US201314439536 |
申请日期 |
2013.10.29 |
| 申请人 |
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS |
发明人 |
Hargis Billy M.;Pumford Neil R.;Morgan Marion;Shivaramaiah Srichaitanya;Tellez Guillermo;Wolfenden Amanda |
| 分类号 |
A61K39/39;A61K39/155;C12N7/00;A61K39/08 |
主分类号 |
A61K39/39 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An adjuvant composition comprising a carbohydrate linked to chitosan to form a Schiff base, and wherein the carbohydrate is mannose. |
| 地址 |
Little Rock AR US |
