| 发明名称 |
TRANSMUCOSAL TAXANE COMPOSITION |
| 摘要 |
The present invention provides a pharmaceutical composition for delivering an active agent taxane through transmucosal administration, more particularly through the buccal mucosa or sublingual mucosa. The present invention provides a method for treating cancer by buccal or sublingual administration of the pharmaceutical composition to a subject. The pharmaceutical composition comprises a taxane, a non-ionic surfactant, a viscosity enhancing agent, an adhesive agent, and an alcohol solvent at pH 4-6. |
| 申请公布号 |
US2015297554(A1) |
申请公布日期 |
2015.10.22 |
| 申请号 |
US201514690289 |
申请日期 |
2015.04.17 |
| 申请人 |
LP PHARMACEUTICAL (XIAMEN) CO., LTD. |
发明人 |
YE Ying;Zhu Janshon |
| 分类号 |
A61K31/337;A61K47/10;A61K47/32;A61K47/26 |
主分类号 |
A61K31/337 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A pharmaceutical formulation comprising 0.15-10% (w/v) of a taxane, 20-60% (w/v) of a non-ionic surfactant, a viscosity enhancing agent to provide a viscosity of 200-400 CP, 2-30% (w/v) of an adhesive agent, and 10-75% (w/v) of ethanol, wherein the pH of the pharmaceutical formulation is 4-6, and the taxane is selected from the group consisting of docetaxel, paclitaxel, cabazitaxel, and larotaxel. |
| 地址 |
Xiamen CN |
