DETECTION DEVICE, METHOD, AND PROGRAM FOR ASSISTING NETWORK ENTROPY-BASED DETECTION OF PRECURSOR TO STATE TRANSITION OF BIOLOGICAL OBJECT

摘要

The invention provides a detection device, method, and program capable of highly accurately detecting a pre-disease state that indicates a precursor to a state transition from a healthy state to a disease state. The following processes are carried out: a process of obtaining measured data on genes, proteins, etc. related to a biological object as high-throughput data (s1), a process of selecting differential biological molecules (s2), a process of calculating the SNE of a local network (s3), a process of selecting a biomarker candidate (s4), a process of calculating an average SNE across the entire network (s5), and a process of determining and detecting whether or not the system is in a pre-disease state (s6).

主权项

1. A detection device for assisting detection of a precursor to a state transition of a biological object to be measured, based on measured data of a plurality of factors obtained by measurement on the biological object, said device comprising:
selection means for selecting those factors for which the measured data shows a time-dependent change beyond a predetermined criterion; microscopic calculation means for calculating, for each factor, a microscopic entropy as understood in statistical mechanics between that factor and every neighboring factor thereof in a network representative of dynamical coupling among the factors obtained based on a correlation of the factors selected by the selection means; and detection means for detecting a factor as a precursor to a state transition when the microscopic entropy calculated by the microscopic calculation means shows a decrease beyond a predetermined detection criterion.