COMPOSITIONS AND METHODS FOR BIOLOGICAL PRODUCTION OF FATTY ACID DERIVATIVES

摘要

The present disclosure provides compositions and methods for biologically producing fatty acid derivatives, such as fatty alcohols, from recombinant C1 metabolizing microorganisms that utilize C1 substrates such as methane or natural gas as a feedstock.

主权项

1. A method for making a fatty acid derivative, comprising culturing a non-natural C1 metabolizing non-photosynthetic microorganism with a C1 substrate feedstock and recovering the fatty acid derivative,
wherein the C1 metabolizing non-photosynthetic microorganism comprises a recombinant nucleic acid molecule encoding a fatty acid converting enzyme, and wherein the C1 metabolizing non-photosynthetic microorganism converts the C1 substrate into a C8-C24 fatty acid derivative comprising a fatty aldehyde, a fatty alcohol, a hydroxy fatty acid, a dicarboxylic acid, or a combination thereof.