LIPID COMPOSITION USED FOR CONSTRUCTION OF LIPOSOMAL GENETIC DRUG CARRIER TARGETED WITH ANTIBODIES, AND USE THEREOF

摘要

The object of the present invention is a lipid composition used for creation of liposome carrier targeted with antibodies for genetic drugs in the form of as ODN, si RNA, mi RNA, ribozyme RNA, and DNAzyme, characterized in that it contains from 35.2% to 45.7% by weight of phosphatidylcholine (PC), from 12.3 to 9.1% by weight of dioleoylphosphatidylethanolamine (DOPE), from 4.9% to 6.4% by weight of 3β-[N-(Dimethylethane)carbamoyl]cholesterol (DC-CHOL), from 10.7% to 16.6% by weight of DSPE-PEG from 4.6% to 6.2% by mass of maleimide DSPE-PEG derivative (DSPE-PEG-Mal), and from 10.6% to 25.7% by mass of a trimethylammonium salt of 1,2-dioleoylpropane (DOTAP) and its use.