| 摘要 |
<p>The present invention relates to a kind of Phosphodiesterase 4 inhibitors without vomiting, which is compounds or a prodrugs or solvates represented by formula (I), R 1 is an independent methoxy, bromine and substituted aryl; X is an optionally substituted six-membered heterocyclic ring; Y is -(CH 2 ) n -, -NH(CH 2 ) n -, and-NH(CH 2 ) n -O-, wherein n is any value among 0, 1, 2 and 3; Z is an optionally substituted aromatic ring or an optionally substituted heteroaromatic ring. The present invention is relates to a kind of Phosphodiesterase 4 inhibitors without vomiting, which is a novel biphenyl series PDE4D inhibitor, and can be applied to treat depression and Alzheimer's disease, improve cognitive ability and avoid vomiting.</p> |
