发明名称 |
ENCAPSULATED DYE COATED NOBLE METAL NANOPARTICLES WITH INCREASED SURFACE ENHANCED RAMAN SCATTERING PROPERTIES AS CONTRAST AGENTS |
摘要 |
The present disclosure provides semiconductor-metal composite nanoparticles with optical properties that are superior to those of pure materials for use as contrast agents. The composites include noble metal nanoparticles having a layer of linker molecules being bound to the surface of the noble metal nanoparticle and a layer of dye molecules bound to the layer of linker molecules. The dye molecules are selected such that they form an ordered structure that exhibits a collective absorption band shift, compared to the individual dye molecule, when bound to the noble metal nanoparticle. This structure is encapsulated in a stabilizing coating layer forming a multi-shell structure with properties suitable for biosensing and other detection applications which exhibit enhanced Raman scattering compared to nanoparticles having dye molecules bound thereto not in the ordered structure. |
申请公布号 |
EP2932243(A1) |
申请公布日期 |
2015.10.21 |
申请号 |
EP20130862128 |
申请日期 |
2013.12.11 |
申请人 |
ZAMECNIK, COLIN R.;WALKER, GILBERT C. |
发明人 |
ZAMECNIK, COLIN R.;WALKER, GILBERT C. |
分类号 |
G01N21/65;B22F1/00;B22F1/02;C12Q1/68;G01N33/483 |
主分类号 |
G01N21/65 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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