Process for predicting hematocrit of whole blood using IR light

摘要

A separation device is disclosed along with systems and methods employing the device in blood processing procedures. In one embodiment, a spinning membrane separator is provided. Automated systems and methods are disclosed for separating a unit of previously-collected whole blood into selected blood components, such as concentrated red cells and plasma, including prediction of the hematocrit of the whole blood using a light source and an optical sensor.

主权项

1. In a blood processing procedure in which blood is processed into one or more blood components with a single-use processing kit, the processing kit including tubing through which the blood is flowed, and a reusable hardware module onto which the processing kit is mounted, the reusable hardware module including a sensing field defined by an infrared light source and an infrared reflectance sensor that receives a segment of the tubing, a method for predicting the hematocrit of the blood comprising:
loading the processing kit onto the hardware module with a segment of the tubing positioned in the sensing field defined by the infrared light source and the infrared reflectance sensor; obtaining an infrared reflectance measurement of the segment of the tubing with either no fluid or a non-reflecting fluid within said segment; flowing blood through the segment of the tubing; obtaining an infrared reflectance measurement of the segment of the tubing with said blood; deriving the natural log of the infrared reflectance measurement attributable to the presence of blood in the segment of the tubing; inputting the natural log of the infrared reflectance attributable to the blood in the segment of the tubing into a correlation equation to arrive at the hematocrit of the blood; outputting the predicted hematocrit of the blood.