发明名称 Tris salts of 8-chloro-3-pentyl-3,7-dihydro-1H-purine-2,6-dione
摘要 The present invention relates to a tris salt of 8-chloro-3-pentyl-3,7-dihydro-1H-purine-2,6-dione of Formula (A) or a pharmaceutically acceptable salt thereof:;;corresponding pharmaceutical formulations, manufacture processes and uses of the aforementioned compound in therapy, particularly in treatment of diseases where under-activation of the HM74A receptor contributes to the disease or where activation of the receptor will be beneficial.
申请公布号 US9163024(B2) 申请公布日期 2015.10.20
申请号 US200913133486 申请日期 2009.12.07
申请人 GlaxoSmithKline LLC 发明人 Esken Holly;Norton Beth Adams
分类号 A61K31/522;C07D473/06;C07D473/04 主分类号 A61K31/522
代理机构 代理人 Hall Linda E.;Lemanowicz John E.
主权项 1. A compound which is crystalline 8-chloro-3-pentyl-3,7-dihydro-1H-purine-2,6-dione tris(hydroxymethyl)aminomethane anhydrate: having an XRPD pattern as shown in FIG. 2.
地址 Wilmington DE US