发明名称 |
Tris salts of 8-chloro-3-pentyl-3,7-dihydro-1H-purine-2,6-dione |
摘要 |
The present invention relates to a tris salt of 8-chloro-3-pentyl-3,7-dihydro-1H-purine-2,6-dione of Formula (A) or a pharmaceutically acceptable salt thereof:;;corresponding pharmaceutical formulations, manufacture processes and uses of the aforementioned compound in therapy, particularly in treatment of diseases where under-activation of the HM74A receptor contributes to the disease or where activation of the receptor will be beneficial. |
申请公布号 |
US9163024(B2) |
申请公布日期 |
2015.10.20 |
申请号 |
US200913133486 |
申请日期 |
2009.12.07 |
申请人 |
GlaxoSmithKline LLC |
发明人 |
Esken Holly;Norton Beth Adams |
分类号 |
A61K31/522;C07D473/06;C07D473/04 |
主分类号 |
A61K31/522 |
代理机构 |
|
代理人 |
Hall Linda E.;Lemanowicz John E. |
主权项 |
1. A compound which is crystalline 8-chloro-3-pentyl-3,7-dihydro-1H-purine-2,6-dione tris(hydroxymethyl)aminomethane anhydrate: having an XRPD pattern as shown in FIG. 2. |
地址 |
Wilmington DE US |