Biosensors and methods for making and using them

摘要

Embodiments of the invention provide analyte sensors having optimized permselective membranes and methods for making and using such sensors. Embodiments of the invention also provide analyte sensors such as those having porous matrices coated with an analyte sensing composition and methods for making and using such sensors. Illustrative embodiments include electrochemical glucose sensors having glucose oxidase coatings.

主权项

1. A composition comprising a porous matrix comprising a lattice of spherical particles having a surface coated with an immobilized enzyme, wherein:
the porous matrix comprises a micro-porous metal that functions as an electrode in an electrochemical sensor, wherein the electrode consumes hydrogen peroxide in the electrochemical sensor; the porous matrix is at least 10, 100, or 1000 microns thick; and the composition is implantable within a mammal.