Osteogenic cell delivery matrix

摘要

Compositions and methods for augmenting bone formation by administering isolated human mesenchymal stem cells (hMSCs) within a matrix provided. By adding calcium and/or phosphate ions to the matrix, one may foster greater bone regeneration.

主权项

1. A composition for augmenting bone formation, the composition comprising a matrix configured to allow growth of bone and/or cartilage, the matrix having a porosity between about 50% to about 70% and comprising stem cells, calcium ions, phosphate ions and demineralized bone matrix, the calcium ions being complexed to the phosphate ions as calcium phosphate ions, wherein the calcium and phosphate ions are available in a quantity to have a biological effect on the stem cells, and the calcium and phosphate ions are present in a ratio of about 1:5 to about 1:3 or about 5:1 to about 3:1.