| 摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: invention relates to selenophene compound of formula (I)or its pharmaceutically acceptable salt. X stands for selenium, Y and Z stand for carbon atoms; or Y stands for selenium, X and Z stand for carbon atoms; or Z stands for selenium, X and Y stand for carbon atoms; A stands for N; B stands for NR, where Ris selected from hydrogen, or alkyl; Ar stands for aryl or heteroaryl ring; aryl represents benzene or naphthalene ring, and heteroaryl represents 6-membered aromatic ring, which contains one, two or three nitrogen atoms; or heteroaryl stands for 5-membered aromatic ring, which contains one or several heteroatoms, selected from sulphur, oxygen and nitrogen, on condition that not more than one oxygen or sulphur atom is present; and such rings include pyridine, pyridazine, pyrazine, pyrimidine, thiophene, furan, pyrrole, pyrazole, imidazole, oxazole, isoxazole, thiazole and isothiazole; optionally substituted with one, two or several groups, independently selected from hydrogen, halogen, thiol, sulphonamide, Calkyl, secondary Calkyl, tertiary Calkyl, Calkinyl, Calkoxycarbonyl and phenyl; R, Rand Rare independently selected from hydrogen, carboxylic acid, amino, nitro, cyano, sulphonic acid, thiol, trihalomethyl, Calkyl, secondary Calkyl, tertiary Calkyl, Calkoxycarbonyl, aminocarbonyl, Calkylaminocarbonyl, di(Calkyl)aminocarbonyl, and phenyl; or Rand Rare bound, and together with atoms, which they are bound to, they form 5-7-membered optionally substituted carbocyclic or perhydroheterocyclic ring, given in invention formula; or Rand Rare bound, and together with atoms, which they are bound to, form optionally substituted aryl or non-substituted heteroaryl ring, fused with selenophene; and aryl represents benzene ring, and heteroaryl represents 6-membered aromatic ring, which contains one nitrogen atom. Methods of obtaining selenophene compound (versions), pharmaceutical composition, methods of treatment or inhibition, or control of cell proliferative disorder are also claimed.EFFECT: invention makes it possible to obtain selenophene compound, which has anticancer activity.29 cl, 2 tbl, 35 ex |
