Therapeutic or prophylactic agent for allergic dermatitis

摘要

A therapeutic or prophylactic agent for allergic dermatitis is disclosed. The therapeutic or prophylactic agent comprises as an effective ingredient a glycine derivative having a specific structure or a pharmaceutically acceptable salt thereof, for example, the below-described compound [(E)-2-(2,6-dichlorobenzamido)-5-[4-(isopropyl-pyrimidin-2-ylamino)phenyl]pent-4-enoic acid]. The therapeutic or prophylactic agent for allergic dermatitis according to the present invention has high therapeutic or prophylactic effect.;

主权项

1. A method for treating allergic dermatitis, comprising administering to a patient an effective amount of a therapeutic agent comprising as an effective ingredient (a) compound of Formula (I): wherein R1 represents hydrogen or C1-C5 alkyl; X independently represents fluoro, chloro, bromo, iodo or C1-C3 alkyl; V represents —CH═CH— or —C≡C—; Y represents Formula (II) or Formula (III): wherein R2 represents C1-C5 alkyl or C1-C3 alkoxy; R3 represents hydrogen or C1-C5 alkyl; m represents an integer of 0 to 3; n represents 0 or 1; p represents an integer of 0 to 2; W represents —O— or —N(R4)— wherein R4 represents hydrogen, C1-C5 alkyl, C3-C6 alkenyl, phenyl, benzyl, benzyl substituted with one or two R5s, tetrahydropyranyl, (CH2)q—O—CH3, pyridylmethyl, —(CH2)q—CN, C4-C7 cycloalkylmethyl or thiazol-4-ylmethyl; R5 represents hydroxy or C1-C3 alkoxy; and q represents an integer of 1 to 3; or (b) a pharmaceutically acceptable salt of the compound of said Formula (I).