| 主权项 |
1. A method of treating Retinitis Pigmentosa (RP), comprising:
administering an effective amount of a synthetic retinyl ester that is a 9-cis-retinyl ester or an 11-cis-retinyl ester to a human subject, wherein RP in the human subject is due to a deficiency in endogenous 11-cis retinal in the eye and wherein when the synthetic retinyl ester is administered to the human subject a functional opsin/chromophore complex is formed in the eye, wherein the 9-cis-retinyl ester has a structure as represented by Formula I or the 11-cis-retinyl ester has a structure as represented by Formula II, wherein A in each formula is CH2OR and R forms a retinyl ester, and the ester substituent of said retinyl ester comprises a carboxylate radical of a C1 to C10 monocarboxylic acid or a C2 to C22 polycarboxylic acid: wherein the ester substituent is selected from the group consisting of formate, acetate, propionate, butyrate, valerate, caproate, heptanoate, caprylate, pelargonate, caprate, oxalate, malonate, succinate, fumarate, malate, glutarate, adipate, pimelate, suberate, azelate, sebacate, citrate, oxaloacetate, and ketoglutarate with the proviso that if the synthetic retinyl ester is an 11-cis-retinyl ester it is not 11-cis-retinyl acetate. |
