发明名称 |
Methods for oxidation of alpha tocotrienol in the presence of non-alpha tocotrienols |
摘要 |
A method of producing alpha-tocotrienol quinone or a stereoisomer thereof, the method comprising selective opening of alpha-tocotrienol chroman to alpha-tocotrienol quinone in the presence of non-alpha tocotrienol chromans by oxidizing alpha-tocotrienol with a metal salt oxidizing agent, wherein the stoichiometric ratio of metal salt oxidizing agent/alpha-tocotrienol is at least 4:1 and wherein said metal oxidizing agent is added in sequential additions, in order to reduce oxidation of any amounts of non-alpha tocotrienol chromans that might have been present in the starting alpha-tocotrienol chroman material. This process uses conditions favoring oxidation rates of the alpha tocotrienol chroman vs. the non-alpha tocotrienol chromans. |
申请公布号 |
US9162957(B2) |
申请公布日期 |
2015.10.20 |
申请号 |
US201214233734 |
申请日期 |
2012.07.19 |
申请人 |
Edison Pharmaceuticals, Inc. |
发明人 |
Mollard Paul |
分类号 |
C07C46/06;C07D311/72;C07C403/08 |
主分类号 |
C07C46/06 |
代理机构 |
Squire Patton Boggs (US) LLP |
代理人 |
Squire Patton Boggs (US) LLP |
主权项 |
1. A method of producing alpha-tocotrienol quinone of Formula I: or a stereoisomer thereof, the method comprising opening of alpha-tocotrienol to alpha-tocotrienol quinone of Formula I in the presence of non-alpha-tocotrienols by oxidizing alpha-tocotrienol with a metal salt oxidizing agent wherein the metal salt oxidizing agent is iron(III) chloride (Fe(III)C13), wherein the stoichiometric ratio of metal salt oxidizing agent/alpha-tocotrienol is at least about 4:1 and wherein said metal oxidizing agent is added in sequential additions. |
地址 |
Mountain View CA US |