Crystalline (6R,7R)-7-{2-(5-amino-[1,2,4] thiadiazol-3-yl)-2-[(Z)-trityloxyimino]-acetylamino}-3-[(R)-1′-tert-butoxycarbonyl-2-oxo-[1,3′]bipyrrolidinyl-(3E)-ylidenemethyl]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester; its manufacture and use

摘要

A solid DMSO solvate of a compound of formula (I) is described, which is a useful intermediate for preparing the broad spectrum antibiotics Ceftobiprole and Ceftobiprole Medocaril.;

主权项

1. A process for the manufacture of a purified form of a compound of formula (I): from a raw form of said compound, comprising the steps of:
converting said raw compound of formula (I) into a solid DMSO solvate;isolating said DMSO solvate;re-dissolving said isolated DMSO solvate in methylene chloride in which said compound of formula (I) precipitates; andisolating said precipitated purified compound of formula (I).