| 主权项 |
1. A compound of formula I, wherein: A represents S; B represents C(—NH—W-D); the bond between B and the NH group is a double bond; X represents —Q-[CRxRy]n—; W represents —[CRxRy]m— or —C(O)—[CRxRy]p—; Q represents a bond, —N(Ra)—, —S—, or —O—; A1 to A5 respectively represent C(R1), C(R2), C(R3), C(R4) and C(R5), or, alternatively, up to two of A1 to A5 may independently represent N; D represents phenyl, pyridyl or pyrimidinyl optionally substituted by one or more R6 groups; Rx and Ry, on each occasion when used herein, are independently selected from H, halo, C1-6 alkyl (optionally substituted by one or more halo atoms), aryl (optionally substituted by one or more halo atoms) or Rx and Ry are linked to form, along with the carbon atom to which they are attached, a non-aromatic 3- to 8-membered ring, optionally containing 1 to 3 heteroatoms selected from O, S and N, which ring is itself optionally substituted by one or more substituents selected from halo or C1-6 alkyl (optionally substituted by one or more halo atoms); R1 to R5 independently represent H, halo, —R7, —CF3, —CN, —NO2, —C(O)R7, —C(O)OR7, —C(O)—N(R7a)R7b, —N(R7a)R7b, —N(R7)3+, —SR7, —OR7, —NH(O)R7, —SO3R7, aryl or heteroaryl (which aryl and heteroaryl groups are themselves optionally and independently substituted by one or more groups selected from halo and R16), or any two of R1 to R5 which are adjacent to each other are optionally linked to form, along with two atoms of the essential benzene ring in the compound of formula I, an aromatic or non-aromatic 3- to 8-membered ring, optionally containing 1 to 3 heteroatoms selected from O, S and N, which ring is itself optionally substituted by one or more substituents selected from halo, —R7, —OR7 and ═O; R6 independently represents, on each occasion when used herein, cyano, —NO2, halo, C1-6 alkyl (which alkyl group is substituted by one or more halo atoms), —OR8, —N(R8)C(O)R8, —NR9R10, —SR11, —Si(R12)3, —OC(O)R13, —C(O)OR13, —C(O)R14, —C(O)NR15aR15b, —S(O)2NR15cR15d, aryl or heteroaryl (which aryl and heteroaryl groups are themselves optionally and independently substituted by one or more groups selected from halo and R16), or any two R6 groups which are adjacent to each other are optionally linked to form, along with two atoms of the essential benzene ring in the compound of formula I, an aromatic or non-aromatic 3- to 8-membered ring, optionally containing 1 to 3 heteroatoms selected from O, S and N, which ring is itself optionally substituted by one or more substituents selected from halo, —R7, —OR7 and ═O; R7, on each occasion when used herein, is selected from H or C1-C6 alkyl, C1-C6 cycloalkyl, aryl and heteroaryl (wherein the latter four groups are optionally substituted by one or more halo atoms); R7a and R7b are independently selected from H, or C1-C6 alkyl, C1-C6 cycloalkyl, aryl and heteroaryl, or R7a and R7b are optionally linked to form, along with the nitrogen atom to which they are attached, an aromatic or non-aromatic 3- to 8-membered ring, optionally containing 1 to 3 heteroatoms selected from O, S and N, which ring is itself optionally substituted by one or more substituents selected from halo, —R7, —OR7 and ═O; Ra, R8, R9, R10, R11, R12, R13, R14, R15a, R15b, R15c and R15d, on each occasion where used herein, independently represent H or R16; R16 represents, on each occasion when used herein, C1-6 alkyl optionally substituted by one or more halo atoms; n represents 1 or 2; m represents 0, 1 or 2; and p represents 0, 1 or 2; or a pharmaceutically acceptable salt or solvate, or a pharmaceutically functional derivative thereof. |
