Sample processing cartridge and method of processing and/or analysing a sample under centrifugal force

摘要

A sample processing cartridge for carrying out processing under centrifugal force acting in at least two directions as the orientation of cartridge relative to centrifugal force is changed, the cartridge comprising: a first cavity adapted to contain a sample; and a second cavity in fluid communication with the first cavity, wherein the first and second cavities are arranged such that the sample in the first cavity is moved therefrom to the second cavity as a centrifugal force acting on the cartridge is changed from a first direction to a second direction, the first cavity is elongated perpendicular to the centrifugal force acting in the first direction, and the second cavity is more shallow than the first cavity and more extended in the direction of the centrifugal force acting in the second direction than the first cavity is extended in the direction of the centrifugal force acting in the first direction.

主权项

1. A method of processing and/or analyzing a sample under centrifugal force, the method comprising:
providing a sample processing cartridge having a first elongated separation cavity adapted to contain the sample and a second cavity in fluid communication with the first elongated separation cavity, the first elongated cavity having a curvature shape extending in a longitudinal direction thereof; providing the sample in the first elongated separation cavity of the sample processing cartridge; subjecting the cartridge to a centrifugal force acting in a first direction, wherein the longitudinal direction of the first elongated separation cavity extends in a plane of the cartridge, perpendicular to the centrifugal force acting in the first direction; and changing the centrifugal force from the first direction to a second direction such that the sample in the first elongated separation cavity is moved therefrom to the second cavity, wherein the second cavity is shallower than the first elongated separation cavity and more extended in the direction of the centrifugal force acting in the second direction than the first elongated separation cavity is extended in the direction of the centrifugal force acting in the first direction, wherein the cartridge is subjected to the centrifugal force by rotating the cartridge about an external axis, and wherein the direction of the centrifugal force is changed by rotating the cartridge about an axis within the cartridge.