Flowable matrix compositions and methods

摘要

Flowable matrix compositions and methods of their use and manufacture are provided. Exemplary compositions may include a flowable, syringeable, putty-like form of acellular human dermal matrix. In some cases, compositions may include a moldable acellular collagen extracellular matrix. In use, the matrix compositions can be used to fill or treat skin voids, channel wounds, and other soft tissue deficiencies.

主权项

1. A soft tissue matrix composition for use in a patient treatment prepared by a method consisting of:
providing a human soft tissue material; processing the human soft tissue material to mechanically disrupt the extracellular matrix collagen or macrostructure and partially disrupt the collagen microfibrillar architecture by a process selected from the group consisting of: (i) cryofracturing the human soft tissue material; (ii) cryofracturing and washing the human soft tissue material; (iii) cryofracturing and triturating the human soft tissue material; and (iv) cryofracturing, triturating, and washing the human soft tissue material, wherein the processed tissue material is in a partially hydrated state, the partial hydration comprising a substantial amount of the natural interstitial water of the human soft tissue material.