Targeted therapeutic nanoparticles

摘要

Disclosure of methods and compositions related to chemical conjugations to nanoparticles of polysaccharides cross-linked to poloxamers as well as nano-sized colloids comprised of polysaccharides and poloxamers. The nanoparticles may be produced by various methods including inverse miniemulsion polymerization processes which create nanogels of desired size, shape, and stability for controlled therapeutic drug delivery, imaging, and theragnostic applications.

主权项

1. A nanoparticle targeting molecule, comprising:
a polymeric network comprising a plurality of first block copolymeric segments are derived from block copolymers comprising at least one block of ethylene oxide monomers and at least one block of propylene oxide monomers and a plurality of second polymeric segments derived from dextran; a polymyxin B targeting agent conjugated to at least a portion of the second polymeric segments of the polymeric network; and an antibacterial encapsulated in the polymeric network.