| 主权项 |
1. A compound according to Formula (I):or a salt thereof, wherein:
R2 and R4 are different and independently are each phenyl substituted with one or more of the same or different R8 groups; R5 is fluoro; R8 is selected from Ra, Rb, Ra substituted with one or more of the same or different Ra or Rb, ORa substituted with one or more of the same or different Ra, —(CH2)m—Rb, —(CHRa)m—Rb, —O—(CH2)m—Rb, —O—(CHRa)m—Rb, —C(O)NH—(CH2)m—Rb, —C(O)NH—(CHRa)m—Rb, —O—(CH2)m—C(O)NH—(CH2)m—Rb, —O—(CHRa)m—C(O)NH—(CHRa)m—Rb, —NH—(CH2)m—Rb or —NH—(CHRa)m—Rb; each Ra is independently selected from hydrogen, (C1-C6)alkyl, (C3-C8)cycloalkyl, cyclohexyl, (C4-C11)cycloalkylalkyl, (C5-C10)aryl, phenyl, (C6-C16) arylalkyl, benzyl, 3-8 membered cycloheteroalkyl, morpholinyl, piperazinyl, homopiperazinyl, piperidinyl, 4-11 membered cycloheteroalkylalkyl, 5-10 membered heteroaryl, or 6-16 membered heteroarylalkyl; each Rb is independently selected from ═O, ORa, (C1-C3) haloalkyloxy, ═S, ═SRa, ═NRa, ═NONRa, —NRcRc, halogen, —CF3, —CN, —OCN, —SCN, —NO, NO2, ═N2, —N3, —S(O)Ra, —S(O)2Ra, —S(O)2ORa, —S(O)2NRcRc, —OS(O)Ra, —OS(O)2Ra, —OS(O)2ORa, —OS(O)2NRcRc, —C(O)Ra, —C(O)ORa, —C(O)NRcRc, —C(NH)NRcRc, OC(O)Ra, —OC(O)ORa, —OC(O)NRcRc, —OC(NH)NRcRc, [NHC(O)]Ra, —[NHC(O)]ORa, [NHC(O)]NRcRc or —[NHC(NH)]NRcRc; each Rc is independently Ra, or, alternatively, each Rc is taken together with the nitrogen atom to which it is bonded to form a 5 to 8-membered cycloheteroalkyl or heteroaryl which may optionally include one or more of the same or different additional heteroatoms and which is optionally substituted with one or more of the same or different Ra or suitable Rb groups; at least one R8 is Rb; and each m is independently an integer from 1 to 3. |
