发明名称 |
Topical compositions and methods for making and using same |
摘要 |
The present invention relates to improved topical gel compositions comprising an active agent, and uses thereof. |
申请公布号 |
US9161914(B2) |
申请公布日期 |
2015.10.20 |
申请号 |
US201414297293 |
申请日期 |
2014.06.05 |
申请人 |
Merz Pharmaceuticals, LLC |
发明人 |
Hardas Bhushan;Dalton Donna |
分类号 |
A61K9/00;A61K9/14;A61K31/74;A01N25/32;A61K9/06;A61K47/38;A61K47/10;A61K47/26;A61K31/137;A61K31/56 |
主分类号 |
A61K9/00 |
代理机构 |
Dechert LLP |
代理人 |
Dechert LLP ;Reid Andrea L. C. |
主权项 |
1. A method of treating a fungal infection in a patient in need thereof, comprising administering to the patient a gel composition consisting essentially of:
(i) naftifine or a pharmaceutically acceptable salt thereof, present in an amount of from about 0.5 wt % to about 4 wt %; (ii) a first solvent which is a glycol solvent, present in an amount of from about 10 wt % to about 25 wt %; (iii) a second solvent which is an alkyl alcohol solvent, present in an amount of from about 10 wt % to about 25 wt %; (iv) a non-carbomer rheology modifier selected from a hydroxy cellulose, present in an amount of from about 0.75 wt % to about 2.25 wt %; (v) a polysorbate solubilizing agent present in an amount of from about 3 wt % to about 8 wt %; (vi) a pH adjuster selected from an amine base; and optionally one or more of: water, a preservative, a chelating agent, a coloring agent, and a fragrance, wherein the gel composition has a pH of about 4.5 to about 6.0. |
地址 |
Raleigh NC US |