Specificity of analyte detection in etalons

摘要

A system and method is provided for detecting concentration of an analyte in a fluid. A first container includes (i) an optical cavity detection region, (ii) a reservoir for one or more modifiers of one or more optical properties of the optical cavity detection region, and (iii) a set of one or more bounding regions through which objects in the fluid can transfer into the container. The optical cavity detection region and the reservoir define separate areas of the first container. The movement of the one or more modifiers between the reservoir and the optical cavity detection region is responsive to changes in concentration of the analyte. A second container includes an optical cavity detection region, and a set of one or more bounding regions through which objects in the fluid can transfer into the container. Also provided are optical components for guiding light into the optical cavity detection regions of the first and second containers.

主权项

1. A system for detecting concentration of an analyte in a fluid, the system comprising:
a first container including (i) an optical cavity detection region having a first side and a second side opposite the first side, the first side and the second side at least partially bounded by light reflective components, and further configured to permit passage of light therethrough, (ii) a reservoir for one or more modifiers of one or more optical properties of said optical cavity detection region, the reservoir configured to define boundaries of the optical cavity detection region, and the reservoir extending substantially from the first side to the second side of the optical cavity detection region and (iii) a set of one or more bounding regions through which objects in the fluid can transfer into the container; the optical cavity detection region and the reservoir defining separate areas of the first container; the movement of said one or more modifiers between said reservoir and said optical cavity detection region being responsive to changes in concentration of said analyte; a second container including an optical cavity detection region having a first side and a second side opposite the first side, the first side and the second side at least partially bounded by light reflective components, and further configured to permit passage of light therethrough, and a set of one or more bounding regions through which objects in the fluid can transfer into the container; an illumination source located a distance external from the first container and the second container and configured to generate the light passing through the optical cavity detection region; and a detector component located a distance external from the first container and the second container on a side opposite the illumination source and configured to detect the light exiting from the optical cavity detection region.