| 摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: invention relates to field of biotechnology, in particular to obtaining stimulated dendritic cells (DC), and can be applied in medicine for immunotherapy of cancer. Mature pro-inflammatory DC is obtained by ex vivo induction of its maturation by processing immature DC with such substances as sodium salt of polyynosinic-polycytidinic acid (poly-Y:C), resiquimod (R848) and interferon-gamma (IFN-g), but not prostaglandin E2 (PGE2). Obtained DC is applied in treatment of cancer in individual by injection into tumour. Said pro-inflammatory mature DC is allogenic with respect to said individual.EFFECT: invention makes it possible to efficiently inhibit proliferation of tumour cells.14 cl, 14 dwg, 6 tbl |
