Amniotic membrane preparations and purified compositions and anti-angiogenesis treatment

摘要

Compositions having a combination of specific biological components have been found to exert a number of useful effects in mammalian cells, including modulating TGF β signaling, apoptosis, and proliferation of mammalian cells, as well as decreasing inflammation in mice. These components can be obtained commercially, or can be prepared from biological tissues such as placental tissues. Placental amniotic membrane (AM) preparations described herein include AM pieces, AM extracts, AM jelly, AM stroma, and mixtures of these compositions with additional components. The compositions can be used to treat various diseases, such as wound healing, inflammation and angiogenesis-related diseases.

主权项

1. A method of inhibiting angiogenesis in an individual in need thereof, comprising administering a ground or pulverized amniotic membrane derived from a frozen or previously frozen placental material.