métodos para preparar nalmefeno de naltrexona em uma reação de wittig, e para isolar o nalmefeno, e, composição farmacêutica

摘要

Method for producing nalmefene hydrochloride from naltrexone, which method is particular well adapted for large-scale industrial application, and has been found to be efficient, to give a high yield and to afford highly pure nalmefene hydrochloride salt.