发明名称 |
composto, composição farmacêutica, uso de um composto, e método para tratar uma doença ou distúrbio. |
摘要 |
The present invention provides novel compounds that inhibit cell proliferation and cell division and that inhibit the activation of Hypoxia Inducible Factor (HIF)-mediated transcription and signaling under hypoxic conditions. In one aspect, the compounds of the present invention are useful for the preparation of a medicament for the treatment or prevention of a disease or disorder selected from the group consisting of an inflammatory disease, a hyperproliferative disease or disorder, a hypoxia-related pathology and a disease characterized by excessive vascularisation. Also provided is a pharmaceutical composition comprising a compound of the invention and a second therapeutic agent or radiation useful for the treatment or prevention of the mentioned diseases or disorders. In a first aspect the present invention relates to a compound having a structure according to formula (I). |
申请公布号 |
BRPI0923856(A2) |
申请公布日期 |
2015.10.20 |
申请号 |
BR2009PI23856 |
申请日期 |
2009.12.30 |
申请人 |
EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL) E ELARA PHARMACEUTICALS GMBH |
发明人 |
ARANTXA ENCINAS LOPEZ;BERND JANSSEN;BERND WENDT;CHRISTOPH SCHULTES;JOCHEN AMMENN;JOE LEWIS;JORGE ALONSO;MARCEL MUELBAIER |
分类号 |
A61K31/18;A61K31/341;A61K31/381;A61K31/41;A61P35/00;C07C311/21;C07D207/416;C07D213/76;C07D231/42;C07D249/14;C07D257/04;C07D261/16;C07D277/52;C07D307/66;C07D333/36 |
主分类号 |
A61K31/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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