摘要 |
Use of polyunsaturated fatty acid derivatives as medicaments or functional foods. The present invention relates to the use of 1,2-fatty acid derivatives in the treatment or prevention of common diseases whose etiology is based on alterations (of any type) of the cell membrane lipids, for example, changes in levels, in the composition or in the structure of these lipids. In addition, for diseases in which the regulation of lipid composition and of the structure of the membranes (or proteins that interact with membranes) causes the reversion of pathological state. |
主权项 |
1. A compound of formula (I)
COOR1—CHR2—(CH2)a—(CH═CH—CH2)b—(CH2)c—CH3 (I)or its pharmaceutically acceptable salts for the treatment of a disease or condition in a subject in need thereof, wherein
(i) a can be any integer value between 0 and 7, (ii) b can be any integer value between 2 and 7, (iii) c can be any integer value between 0 to 7, (iv) R1 is a radical selected from the group consisting of H, Na, K, CH3O, CH3—CH2O and OPO(O—CH2—CH3)2, and, (v) R2 is a radical selected from the group consisting of OH, OCH3, O—CH3COOH, CH3, C1, CH2OH, OPO(O—CH2—CH3)2, NOH, F, HCOO and N(OCH2CH3)2, wherein when a=6, b=2 and c=3, and R2 is OH, R1 is not H, and wherein when a=2, b=4 and c=3, and R2 is OH or CH3, R1 is not H, and wherein when a=1, b=6 and c=0, and R2 is CH3, R1 is not H; and wherein when a=5, b=3 and c=3, and R2 is OCH3, CH3, CH2OH, F or HCOO, R1 is not H. |